Destabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach

BACKGROUND: The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. Some loss-of-function mutations of the TWIST1 gene have been shown to cause an autosomal dominant craniosynostosis, known as the Saethre-Chotzen syndrome (SCS). Although the functiona...

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Detalles Bibliográficos
Autores principales: Bouard, Charlotte, Terreux, Raphael, Tissier, Agnès, Jacqueroud, Laurent, Vigneron, Arnaud, Ansieau, Stéphane, Puisieux, Alain, Payen, Léa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437649/
https://www.ncbi.nlm.nih.gov/pubmed/28521820
http://dx.doi.org/10.1186/s12900-017-0076-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437649/
https://www.ncbi.nlm.nih.gov/pubmed/28521820
http://dx.doi.org/10.1186/s12900-017-0076-x

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