Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors

[Image: see text] The conformational analysis of glycosidases affords a route to their specific inhibition through transition-state mimicry. Inspired by the rapid reaction rates of cyclophellitol and cyclophellitol aziridine—both covalent retaining β-glucosidase inhibitors—we postulated that the cor...

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Detalles Bibliográficos
Autores principales: Beenakker, Thomas J. M., Wander, Dennis P. A., Offen, Wendy A., Artola, Marta, Raich, Lluís, Ferraz, Maria J., Li, Kah-Yee, Houben, Judith H. P. M., van Rijssel, Erwin R., Hansen, Thomas, van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Rovira, Carme, Davies, Gideon J., Overkleeft, Herman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437670/
https://www.ncbi.nlm.nih.gov/pubmed/28463498
http://dx.doi.org/10.1021/jacs.7b01773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437670/
https://www.ncbi.nlm.nih.gov/pubmed/28463498
http://dx.doi.org/10.1021/jacs.7b01773

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