Development of a Scalable Process for the Synthesis of DNDI-VL-2098: A Potential Preclinical Drug Candidate for the Treatment of Visceral Leishmaniasis

[Image: see text] A process suitable for kilogram-scale synthesis of (2R)-2-methyl-6-nitro-2-{[4-(trifluoromethoxy)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole (DNDI-VL-2098, 2), a preclinical drug candidate for the treatment of visceral leishmaniasis, is described. The four-step synthesis...

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Detalles Bibliográficos
Autores principales: Satam, Vijay S., Pedada, Srinivasa Rao, Kamaraj, Pasumpon, Antao, Nakita, Singh, Apoorva, Hindupur, Rama Mohan, Pati, Hari N., Thompson, Andrew M., Launay, Delphine, Martin, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437808/
https://www.ncbi.nlm.nih.gov/pubmed/28539754
http://dx.doi.org/10.1021/acs.oprd.6b00331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437808/
https://www.ncbi.nlm.nih.gov/pubmed/28539754
http://dx.doi.org/10.1021/acs.oprd.6b00331

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