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Practical Synthesis of the Bicyclic Darunavir Side Chain: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol from Monopotassium Isocitrate

[Image: see text] A practical synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol—a key intermediate in the synthesis of darunavir—from monopotassium isocitrate is described. The isocitric acid salt, obtained from a high-yielding fermentation fed by sunflower oil, was converted in several steps...

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Detalles Bibliográficos
Autores principales: Moore, Gary L., Stringham, Rodger W., Teager, David S., Yue, Tai-Yuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437813/
https://www.ncbi.nlm.nih.gov/pubmed/28539755
http://dx.doi.org/10.1021/acs.oprd.6b00377