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Widespread position-specific conservation of synonymous rare codons within coding sequences
Synonymous rare codons are considered to be sub-optimal for gene expression because they are translated more slowly than common codons. Yet surprisingly, many protein coding sequences include large clusters of synonymous rare codons. Rare codons at the 5’ terminus of coding sequences have been shown...
Autores principales: | Chaney, Julie L., Steele, Aaron, Carmichael, Rory, Rodriguez, Anabel, Specht, Alicia T., Ngo, Kim, Li, Jun, Emrich, Scott, Clark, Patricia L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438181/ https://www.ncbi.nlm.nih.gov/pubmed/28475588 http://dx.doi.org/10.1371/journal.pcbi.1005531 |
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