QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

BACKGROUND: Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM1 and PIM2 inhibitors having pIC(50) ranging from 5.55 to 9 µM and from 4.66 to...

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Detalles Bibliográficos
Autores principales: Aouidate, Adnane, Ghaleb, Adib, Ghamali, Mounir, Chtita, Samir, Choukrad, M’barek, Sbai, Abdelouahid, Bouachrine, Mohammed, Lakhlifi, Tahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438336/
https://www.ncbi.nlm.nih.gov/pubmed/29086822
http://dx.doi.org/10.1186/s13065-017-0269-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438336/
https://www.ncbi.nlm.nih.gov/pubmed/29086822
http://dx.doi.org/10.1186/s13065-017-0269-1

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