FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy

FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated. Autophagy has a protective effect on acute liver injury. However, the...

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Detalles Bibliográficos
Autores principales: Guo, Enshuang, Li, Renlong, Yang, Jiankun, Zhang, Jun, Li, Anyi, Yang, Yan, Liu, Shenpei, Liu, Anding, Jiang, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438370/
https://www.ncbi.nlm.nih.gov/pubmed/28526886
http://dx.doi.org/10.1038/s41598-017-02318-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438370/
https://www.ncbi.nlm.nih.gov/pubmed/28526886
http://dx.doi.org/10.1038/s41598-017-02318-7

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