2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway

Oxidative stress causes significant increases in both cholesterol uptake and intracellular accumulation of the aging biomarker lipofuscin. Here we show that HPβCD addition mitigates these adverse effects in human fibroblasts by significantly reducing LDLr and SREBP1 gene expression. In the absence o...

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Detalles Bibliográficos
Autores principales: Gaspar, Jason, Mathieu, Jacques, Alvarez, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438378/
https://www.ncbi.nlm.nih.gov/pubmed/28526856
http://dx.doi.org/10.1038/s41598-017-02387-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438378/
https://www.ncbi.nlm.nih.gov/pubmed/28526856
http://dx.doi.org/10.1038/s41598-017-02387-8

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