Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer’s Disease Phase IIa and Expanded Access Trials

Bryostatin 1, a potent activator of protein kinase C epsilon (PKCɛ), has been shown to reverse synaptic loss and facilitate synaptic maturation in animal models of Alzheimer’s disease (AD), Fragile X, stroke, and other neurological disorders. In a single-dose (25 μg/m(2)) randomized double-blind Pha...

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Detalles Bibliográficos
Autores principales: Nelson, Thomas J., Sun, Miao-Kun, Lim, Chol, Sen, Abhik, Khan, Tapan, Chirila, Florin V., Alkon, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438479/
https://www.ncbi.nlm.nih.gov/pubmed/28482641
http://dx.doi.org/10.3233/JAD-170161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438479/
https://www.ncbi.nlm.nih.gov/pubmed/28482641
http://dx.doi.org/10.3233/JAD-170161

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