Cargando…

A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway

Metabolic reprogramming is critical for cancer cell proliferation. Glutaminolysis which provides cancer cells with bioenergetics and intermediates for macromolecular synthesis have been intensively studied in recent years. Glutaminase C (GAC) is the first and rate-limiting enzyme in glutaminolysis a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Tianyu, Guo, Meng, Zhang, Tingting, Gan, Mingxi, Xie, Caifeng, Wang, Jian-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438631/ https://www.ncbi.nlm.nih.gov/pubmed/28039459 http://dx.doi.org/10.18632/oncotarget.14188

Ejemplares similares

The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells
por: Wang, Diancheng, et al.
Publicado: (2016)

TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins
por: Zhan, Weihua, et al.
Publicado: (2015)

Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer
por: Xie, Caifeng, et al.
Publicado: (2015)

A Combination of Glutaminase Inhibitor 968 and PD-L1 Blockade Boosts the Immune Response against Ovarian Cancer
por: Wang, Jing-Jing, et al.
Publicado: (2021)

Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis
por: Wang, Tao, et al.
Publicado: (2022)

Compound 968 reverses adriamycin resistance in breast cancer MCF-7(ADR) cells via inhibiting P-glycoprotein function independently of glutaminase
por: Yang, Ronghui, et al.
Publicado: (2021)

Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis
por: Han, Tianyu, et al.
Publicado: (2018)

EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer
por: He, Yiming, et al.
Publicado: (2021)

Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
por: Zhang, Xiangchao, et al.
Publicado: (2023)

Evaluation of 968 children with corrosive substance ingestion
por: Karaman, İbrahim, et al.
Publicado: (2015)

Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome
por: Khoury, Elizabeth Smith, et al.
Publicado: (2020)

A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells
por: Soto-Gamez, Abel, et al.
Publicado: (2020)

Identification and characterization of a novel glutaminase inhibitor
por: Cederkvist, Henning, et al.
Publicado: (2021)

The pattern of gynecological malignancies in 968 cases from Pakistan
por: Jamal, Shahid, et al.
Publicado: (2006)

Targeting glutaminase to starve lymphoma cells
por: Dumontet, Charles
Publicado: (2022)

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
por: Lukey, Michael J., et al.
Publicado: (2016)

Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells
por: Thompson, Ravyn M., et al.
Publicado: (2017)

ERK inhibitor ASN007 effectively overcomes acquired resistance to EGFR inhibitor in non‐small cell lung cancer
por: Ku, Bo Mi, et al.
Publicado: (2022)

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells
por: Lee, Yue-Zhi, et al.
Publicado: (2014)

Glutaminase inhibition in renal cell carcinoma therapy
por: Raczka, Aleksandra M., et al.
Publicado: (2019)

Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
por: López de la Oliva, Amada R., et al.
Publicado: (2020)

Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration
por: Lin, Shuhao, et al.
Publicado: (2021)

Endogenous thrombopoietin promotes non‐small‐cell lung carcinoma cell proliferation and migration by regulating EGFR signalling
por: Zou, Zifang, et al.
Publicado: (2020)

Correction to Lancet Planet Health 2022; 6: e968–76
Publicado: (2023)

T220. THE GLUTAMINASE INHIBITOR EBSELEN PREVENTS AMPHETAMINE SENSITIZATION IN MICE
por: Heffetz-Giterman, Lior, et al.
Publicado: (2018)

Governing glutaminolysis by regulation of glutaminase succinylation
por: Ma, Qingxia, et al.
Publicado: (2021)

High mobility group box 1 regulates gastric cancer cell proliferation and migration via RAGE-mTOR/ERK feedback loop
por: Tang, Tuo, et al.
Publicado: (2021)

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition
por: Ulanet, Danielle, et al.
Publicado: (2014)

Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition
por: Ulanet, Danielle B., et al.
Publicado: (2014)

Erk1 and Erk2 Regulate Endothelial Cell Proliferation and Migration during Mouse Embryonic Angiogenesis
por: Srinivasan, Ruchika, et al.
Publicado: (2009)

OXCT1 regulates NF-κB signaling pathway through β-hydroxybutyrate-mediated ketone body homeostasis in lung cancer
por: Lu, Zhuo, et al.
Publicado: (2022)

Targeting glutaminase and mTOR
por: Tanaka, Kazuhiro, et al.
Publicado: (2015)

Human Papillomavirus Prevalence and Type Distribution Among 968 Women in South Korea
por: So, Kyeong A, et al.
Publicado: (2016)

Self-Assembled Micellar Glutaminase Allosteric Inhibitor for Effective Therapeutic Intervention
por: Fang, Jinzhang, et al.
Publicado: (2022)

Author Correction: Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
por: López de la Oliva, Amada R., et al.
Publicado: (2021)

RF04 | PSUN135 Genetic Inactivation of Glutaminase Reduces Amino Acid Induced Alpha Cell Proliferation
por: Shou, Matthew, et al.
Publicado: (2022)

Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration
por: Wang, Kun, et al.
Publicado: (2019)

Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration
por: Wang, Kun, et al.
Publicado: (2022)

The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma
por: Emberley, Ethan, et al.
Publicado: (2021)

DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells
por: He, Shengli, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3svjs4sufatsqf8cabhc3immeg