HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model

T lymphocytes against tumor-specific mutated neoantigens can induce tumor regression. Also, the size of the immunogenic cancer mutanome is supposed to correlate with the clinical efficacy of checkpoint inhibition. Herein, we studied the susceptibility of tumor cell lines from lymph node metastases o...

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Detalles Bibliográficos
Autores principales: Schrörs, Barbara, Lübcke, Silke, Lennerz, Volker, Fatho, Martina, Bicker, Anne, Wölfel, Catherine, Derigs, Patrick, Hankeln, Thomas, Schadendorf, Dirk, Paschen, Annette, Wölfel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438652/
https://www.ncbi.nlm.nih.gov/pubmed/28423700
http://dx.doi.org/10.18632/oncotarget.16048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438652/
https://www.ncbi.nlm.nih.gov/pubmed/28423700
http://dx.doi.org/10.18632/oncotarget.16048

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