Cargando…

Stellettin B induces apoptosis in human chronic myeloid leukemia cells via targeting PI3K and Stat5

Novel agents are still urgently expected for therapy of chronic myeloid leukemia (CML). The in vitro anti-leukemia activity of Stellettin B (Stel B), a triterpenoid we isolated from marine sponge Jaspis stellifera, on human CML K562 and KU812 cells was recently investigated. Stel B inhibited K562 an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yali, Zhou, Qianxiang, Zhang, Lei, Zhong, Yuxu, Fan, Guanwei, Zhang, Zhe, Wang, Ran, Jin, Meihua, Qiu, Yuling, Kong, Dexin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438702/ https://www.ncbi.nlm.nih.gov/pubmed/28423649 http://dx.doi.org/10.18632/oncotarget.15957

Ejemplares similares

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway
por: Wang, Ran, et al.
Publicado: (2016)

In Vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells
por: Tang, Sheng-An, et al.
Publicado: (2014)

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells
por: Zhou, Qianxiang, et al.
Publicado: (2016)

Antiproliferative effect of ZSTK474 alone or in combination with chemotherapeutic drugs on HL60 and HL60/ADR cells
por: Zhou, Qianxiang, et al.
Publicado: (2017)

Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination Repair
por: Peng, Xin, et al.
Publicado: (2022)

DT-13 Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells Through Blocking PI3K/Akt Pathway
por: Wang, Zhengming, et al.
Publicado: (2018)

Corrigendum: DT-13 Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells Through Blocking PI3K/Akt Pathway
por: Wang, Zhengming, et al.
Publicado: (2020)

Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair
por: Peng, Xin, et al.
Publicado: (2023)

Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells
por: Jin, Meihua, et al.
Publicado: (2011)

Atorvastatin Exerts Antileukemia Activity via Inhibiting Mevalonate-YAP Axis in K562 and HL60 Cells
por: Zhang, Lei, et al.
Publicado: (2019)

Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure
por: Jia, Wenqing, et al.
Publicado: (2022)

Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy
por: Peng, Xin, et al.
Publicado: (2021)

Correction to: Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy
por: Peng, Xin, et al.
Publicado: (2021)

ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells
por: Wang, Yaochen, et al.
Publicado: (2016)

In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway
por: Feng, Chien-Wei, et al.
Publicado: (2019)

In Vitro Antimetastatic Effect of Phosphatidylinositol 3-Kinase Inhibitor ZSTK474 on Prostate Cancer PC3 Cells
por: Zhao, Wennan, et al.
Publicado: (2013)

Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
por: Chang, Chun-Han, et al.
Publicado: (2023)

Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mTOR signaling pathway
por: Hao, Yanmei, et al.
Publicado: (2019)

Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways
por: Tsai, Tsung-Chang, et al.
Publicado: (2022)

Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2022)

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia
por: Annageldiyev, Charyguly, et al.
Publicado: (2020)

PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway
por: Wang, Fang, et al.
Publicado: (2022)

Spinacetin Suppresses the Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mouse Model
por: Ji, Ning, et al.
Publicado: (2018)

Anti-Invasion and Antiangiogenic Effects of Stellettin B through Inhibition of the Akt/Girdin Signaling Pathway and VEGF in Glioblastoma Cells
por: Cheng, Shu-Yu, et al.
Publicado: (2019)

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2023)

MEK/ERK Dependent Activation of STAT1 Mediates Dasatinib-Induced Differentiation of Acute Myeloid Leukemia
por: Fang, Yanfen, et al.
Publicado: (2013)

Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells
por: Akhtar, Nosheen, et al.
Publicado: (2020)

Stellettin B-Induced Oral Cancer Cell Death via Endoplasmic Reticulum Stress–Mitochondrial Apoptotic and Autophagic Signaling Pathway
por: Kuo, Tsu-Jen, et al.
Publicado: (2022)

Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner
por: Peña-Martínez, P, et al.
Publicado: (2018)

Lansoprazole Alone or in Combination With Gefitinib Shows Antitumor Activity Against Non-small Cell Lung Cancer A549 Cells in vitro and in vivo
por: Zhao, Xiaoxia, et al.
Publicado: (2021)

Pharmacologic inhibition of STAT5 in acute myeloid leukemia
por: Wingelhofer, Bettina, et al.
Publicado: (2018)

The Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia
por: Moser, Bernhard, et al.
Publicado: (2021)

Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1
por: Gao, Shan, et al.
Publicado: (2022)

CDA gene silencing regulated the proliferation and apoptosis of chronic myeloid leukemia K562 cells
por: Wei, Xiao-Fang, et al.
Publicado: (2018)

Alisol B 23-Acetate Inhibits IgE/Ag-Mediated Mast Cell Activation and Allergic Reaction
por: Shao, Chen, et al.
Publicado: (2018)

Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K/Akt pathway
por: Wang, Yingying, et al.
Publicado: (2021)

A pyridinesulfonamide derivative FD268 suppresses cell proliferation and induces apoptosis via inhibiting PI3K pathway in acute myeloid leukemia
por: Chen, Yi, et al.
Publicado: (2022)

Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism
por: ZHANG, GANG, et al.
Publicado: (2014)

Targeting c-Jun in A549 Cancer Cells Exhibits Antiangiogenic Activity In Vitro and In Vivo Through Exosome/miRNA-494-3p/PTEN Signal Pathway
por: Shao, Chen, et al.
Publicado: (2021)

STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells
por: Pan, Shunli, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s3avb0beld7hvt3h0h17tuqpvj