Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor

Uridine diphosphate-glucuronosyltransferase (UGT) 2B7, as one of significant drug enzymes, is responsible on the glucuronidation of abundant endobiotics or xenobiotics. We here report that it is markedly repressed in the tumor tissues of colorectal carcinoma (CRC) patients. Accordingly, morphine in...

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Detalles Bibliográficos
Autores principales: Yang, Zi-Zhao, Li, Li, Xu, Ming-Cheng, Ju, Hai-Xing, Hao, Miao, Gu, Jing-Kai, Wang, Zai-Jie Jim, Jiang, Hui-Di, Yu, Lu-Shan, Zeng, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438719/
https://www.ncbi.nlm.nih.gov/pubmed/28418861
http://dx.doi.org/10.18632/oncotarget.16251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438719/
https://www.ncbi.nlm.nih.gov/pubmed/28418861
http://dx.doi.org/10.18632/oncotarget.16251

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