Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

Activation of the Hedgehog pathway has been implicated in the pathogenesis of several tumor types including myeloid leukemia. Previously we demonstrated that overexpression of Hedgehog downstream mediators GLI1/2 confers an adverse prognosis to patients with acute myeloid leukemia (AML) and is corre...

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Detalles Bibliográficos
Autores principales: Latuske, Emily-Marie, Stamm, Hauke, Klokow, Marianne, Vohwinkel, Gabi, Muschhammer, Jana, Bokemeyer, Carsten, Jücker, Manfred, Kebenko, Maxim, Fiedler, Walter, Wellbrock, Jasmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438723/
https://www.ncbi.nlm.nih.gov/pubmed/28418873
http://dx.doi.org/10.18632/oncotarget.16304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438723/
https://www.ncbi.nlm.nih.gov/pubmed/28418873
http://dx.doi.org/10.18632/oncotarget.16304

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