Cargando…

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

Activation of the Hedgehog pathway has been implicated in the pathogenesis of several tumor types including myeloid leukemia. Previously we demonstrated that overexpression of Hedgehog downstream mediators GLI1/2 confers an adverse prognosis to patients with acute myeloid leukemia (AML) and is corre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Latuske, Emily-Marie, Stamm, Hauke, Klokow, Marianne, Vohwinkel, Gabi, Muschhammer, Jana, Bokemeyer, Carsten, Jücker, Manfred, Kebenko, Maxim, Fiedler, Walter, Wellbrock, Jasmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438723/ https://www.ncbi.nlm.nih.gov/pubmed/28418873 http://dx.doi.org/10.18632/oncotarget.16304

Ejemplares similares

Mebendazole Mediates Proteasomal Degradation of GLI Transcription Factors in Acute Myeloid Leukemia
por: Freisleben, Fabian, et al.
Publicado: (2021)

Downregulation of GLI3 Expression Mediates Chemotherapy Resistance in Acute Myeloid Leukemia
por: Freisleben, Fabian, et al.
Publicado: (2020)

Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option
por: Stamm, Hauke, et al.
Publicado: (2018)

Overexpression of Gremlin-1 in Patients with Loeys-Dietz Syndrome: Implications on Pathophysiology and Early Disease Detection
por: Wellbrock, Jasmin, et al.
Publicado: (2014)

Bone Marrow-Resident Vδ1 T Cells Co-express TIGIT With PD-1, TIM-3 or CD39 in AML and Myeloma
por: Brauneck, Franziska, et al.
Publicado: (2021)

Combination therapy targeting integrins reduces glioblastoma tumor growth through antiangiogenic and direct antitumor activity and leads to activation of the pro-proliferative prolactin pathway
por: Oliveira-Ferrer, Leticia, et al.
Publicado: (2013)

The BET bromodomain inhibitor ZEN-3365 targets the Hedgehog signaling pathway in acute myeloid leukemia
por: Wellbrock, Jasmin, et al.
Publicado: (2021)

The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia
por: Velthaus, Arne, et al.
Publicado: (2019)

Immunosuppressive M2 TAMs represent a promising target population to enhance phagocytosis of ovarian cancer cells in vitro
por: Brauneck, Franziska, et al.
Publicado: (2023)

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
por: Brauneck, Franziska, et al.
Publicado: (2022)

Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models
por: Mali, Raghuveer Singh, et al.
Publicado: (2020)

Increased frequency of TIGIT(+)CD73-CD8(+) T cells with a TOX(+) TCF-1low profile in patients with newly diagnosed and relapsed AML
por: Brauneck, F., et al.
Publicado: (2021)

TNF-α enhances the effect of TGF-β on Gli2 expression in the KG-1 leukemic cell line
por: LI, ZHE, et al.
Publicado: (2014)

TGF-β Superfamily Receptors—Targets for Antiangiogenic Therapy?
por: Otten, Jasmin, et al.
Publicado: (2010)

Combined Blockade of TIGIT and CD39 or A2AR Enhances NK-92 Cell-Mediated Cytotoxicity in AML
por: Brauneck, Franziska, et al.
Publicado: (2021)

Acute Myeloid Leukemia and the Bone Marrow Niche—Take a Closer Look
por: Behrmann, Lena, et al.
Publicado: (2018)

Tissue-Specific Expression of TIGIT, PD-1, TIM-3, and CD39 by γδ T Cells in Ovarian Cancer
por: Weimer, Pauline, et al.
Publicado: (2022)

Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia
por: Lee, Hyo Jeong, et al.
Publicado: (2017)

Characterization of FLT3-ITD(mut) acute myeloid leukemia: molecular profiling of leukemic precursor cells
por: Travaglini, Serena, et al.
Publicado: (2020)

Soluble Flt-1 Gene Delivery in Acute Myeloid Leukemic Cells Mediating a Nonviral Gene Carrier
por: Amini, Razieh, et al.
Publicado: (2013)

Correction: Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia
por: Lee, Hyo Jeong, et al.
Publicado: (2018)

Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells
por: Chueahongthong, Fah, et al.
Publicado: (2022)

Elevated frequencies of leukemic myeloid and plasmacytoid dendritic cells in acute myeloid leukemia with the FLT3 internal tandem duplication
por: Rickmann, Mareike, et al.
Publicado: (2011)

Pan-RAF Inhibition Shows Anti-Leukemic Activity in RAS-Mutant Acute Myeloid Leukemia Cells and Potentiates the Effect of Sorafenib in Cells with FLT3 Mutation
por: Khoury, Joseph D., et al.
Publicado: (2020)

Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones
por: Al-Mawali, Adhra, et al.
Publicado: (2016)

FLT3-ITD cooperates with Rac1 to modulate the sensitivity of leukemic cells to chemotherapeutic agents via regulation of DNA repair pathways
por: Wu, Min, et al.
Publicado: (2019)

Co-Treatments of Edible Curcumin from Turmeric Rhizomes and Chemotherapeutic Drugs on Cytotoxicity and FLT3 Protein Expression in Leukemic Stem Cells
por: Chueahongthong, Fah, et al.
Publicado: (2021)

P421: TARGETED DISRUPTION OF HUMAN FLT3 ERADICATES LEUKEMIC STEM CELLS WITHOUT HARMING HEALTHY HEMATOPOIETIC STEM CELLS
por: Araújo, Joana, et al.
Publicado: (2023)

Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells
por: Chen, Fangli, et al.
Publicado: (2016)

The tripeptide N-Cbz-βGly-Gly-Gly-Obz
por: Nicholas, Sumesh
Publicado: (2015)

Preparation of Zn−Gly and Se−Gly and Their Effects on the Nutritional Quality of Tea (Camellia sinensis)
por: Li, Feixia, et al.
Publicado: (2023)

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9(+) leukemic cells
por: Carretta, Marco, et al.
Publicado: (2017)

Effects of plant-derived anti-leukemic drugs on individualized leukemic cell population profiles in Egyptian patients
por: ABOUL-SOUD, MOURAD A. M., et al.
Publicado: (2016)

Effect of leukapheresis on pain reduction in leukemic priapism
por: Noushad, Shahida, et al.
Publicado: (2022)

C(60) Fullerene as an Effective Nanoplatform of Alkaloid Berberine Delivery into Leukemic Cells
por: Grebinyk, Anna, et al.
Publicado: (2019)

Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo
por: Zhu, Haiyan, et al.
Publicado: (2018)

Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells
por: Dupont, Marine, et al.
Publicado: (2022)

Evi1 Counteracts Anti-Leukemic and Stem Cell Inhibitory Effects of All-Trans Retinoic Acid on Flt3-ITD/Npm1c-Driven Acute Myeloid Leukemia Cells
por: Nguyen, Chi Huu, et al.
Publicado: (2020)

Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells
por: Horvat, Luka, et al.
Publicado: (2018)

Medicinal Plants with Anti-Leukemic Effects: A Review
por: Maher, Tahani, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ha8epthvnit5oc0o2ml4pg5ump