Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages

Autophagy plays a pro-survival role in the tamoxifen-resistant breast cancer cells. Herein we found that autophagy was concomitantly induced in tamoxifen-resistant MCF-7 (MCF-7(TR5)) cells through the dissociation of Bcl-2 from Beclin 1 and subsequent enhancement of interaction among the ATG14-Becli...

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Detalles Bibliográficos
Autores principales: Qi, Hongyi, Jiang, Zhuyun, Wang, Chengqiang, Yang, Yi, Li, Li, He, Hui, Yu, Zanyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438731/
https://www.ncbi.nlm.nih.gov/pubmed/28431397
http://dx.doi.org/10.18632/oncotarget.16832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438731/
https://www.ncbi.nlm.nih.gov/pubmed/28431397
http://dx.doi.org/10.18632/oncotarget.16832

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