Z-ligustilide restores tamoxifen sensitivity of ERα negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERα

Emerging evidence indicates epigenetic modification represses estrogen receptor α (ERα) and contributes to the resistance to tamoxifen in aggressive ERα-negative (ERα(−)) breast cancer. Z-ligustilide is a major compound in Radix Angelica sinensis, an herb from traditional Chinese medicine (TCM) most...

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Detalles Bibliográficos
Autores principales: Ma, Hui, Li, Li, Dou, Guojun, Wang, Chengqiang, Li, Juan, He, Hui, Wu, Mingxia, Qi, Hongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438733/
https://www.ncbi.nlm.nih.gov/pubmed/28415616
http://dx.doi.org/10.18632/oncotarget.16440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438733/
https://www.ncbi.nlm.nih.gov/pubmed/28415616
http://dx.doi.org/10.18632/oncotarget.16440

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