Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment

BACKGROUND: The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative stress, and chemoresistant cancer cells express high levels of ALDH enzymes, we...

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Detalles Bibliográficos
Autores principales: Kim, Jeewon, Chen, Che-Hong, Yang, Jieying, Mochly-Rosen, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439151/
https://www.ncbi.nlm.nih.gov/pubmed/28532411
http://dx.doi.org/10.1186/s12929-017-0338-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439151/
https://www.ncbi.nlm.nih.gov/pubmed/28532411
http://dx.doi.org/10.1186/s12929-017-0338-8

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