Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733

Genetic manipulation of the deadly malaria parasite Plasmodium falciparum remains challenging, but the rise of CRISPR/Cas9-based genome editing tools is increasing the feasibility of altering this parasite’s genome in order to study its biology. Of particular interest is the investigation of drug ta...

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Detalles Bibliográficos
Autores principales: Crawford, Emily D., Quan, Jenai, Horst, Jeremy A., Ebert, Daniel, Wu, Wesley, DeRisi, Joseph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439709/
https://www.ncbi.nlm.nih.gov/pubmed/28542423
http://dx.doi.org/10.1371/journal.pone.0178163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439709/
https://www.ncbi.nlm.nih.gov/pubmed/28542423
http://dx.doi.org/10.1371/journal.pone.0178163

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