A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response

Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription. Using a whole-genome RNA interference screen, we unc...

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Detalles Bibliográficos
Autores principales: Pappalardo, Zachary, Gambhir Chopra, Deeksha, Hennings, Thomas G., Richards, Hunter, Choe, Justin, Yang, Katherine, Baeyens, Luc, Ang, Kenny, Chen, Steven, Arkin, Michelle, German, Michael S., McManus, Michael T., Ku, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440024/
https://www.ncbi.nlm.nih.gov/pubmed/28246293
http://dx.doi.org/10.2337/db16-0962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440024/
https://www.ncbi.nlm.nih.gov/pubmed/28246293
http://dx.doi.org/10.2337/db16-0962

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