FH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through Tankyrases

Osteosarcoma (OS) is an aggressive primary bone tumor which exhibits aberrantly activated Wnt signaling. The canonical Wnt signaling cascade has been shown to drive cancer progression and metastasis through the activation of β-catenin. Hence, small molecule inhibitors of Wnt targets are being explor...

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Detalles Bibliográficos
Autores principales: Gustafson, Carl T., Mamo, Tewodros, Shogren, Kristen L., Maran, Avudaiappan, Yaszemski, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440578/
https://www.ncbi.nlm.nih.gov/pubmed/28588489
http://dx.doi.org/10.3389/fphar.2017.00285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440578/
https://www.ncbi.nlm.nih.gov/pubmed/28588489
http://dx.doi.org/10.3389/fphar.2017.00285

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