Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design

The outer-domain core of gp120 may serve as a better HIV vaccine immunogen than the full-length gp120 because of its greater stability and immunogenicity. In our previous report, we introduced two disulfide bonds to the outer-domain core of gp120 to fix its conformation into a CD4-bound state, which...

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Detalles Bibliográficos
Autores principales: Hu, Duoyi, Bowder, Dane, Wei, Wenzhong, Thompson, Jesse, Wilson, Mark A., Xiang, Shi-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440730/
https://www.ncbi.nlm.nih.gov/pubmed/28461065
http://dx.doi.org/10.1016/j.vaccine.2017.04.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440730/
https://www.ncbi.nlm.nih.gov/pubmed/28461065
http://dx.doi.org/10.1016/j.vaccine.2017.04.054

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