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Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design
The outer-domain core of gp120 may serve as a better HIV vaccine immunogen than the full-length gp120 because of its greater stability and immunogenicity. In our previous report, we introduced two disulfide bonds to the outer-domain core of gp120 to fix its conformation into a CD4-bound state, which...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440730/ https://www.ncbi.nlm.nih.gov/pubmed/28461065 http://dx.doi.org/10.1016/j.vaccine.2017.04.054 |