Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription

Mitochondria are the main consumers of molecular O(2) in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α). While a number of mechanisms in the oxygen-dependent HIF-α regula...

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Detalles Bibliográficos
Autores principales: Shvetsova, Antonina N., Mennerich, Daniela, Kerätär, Juha M., Hiltunen, J. Kalervo, Kietzmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440747/
https://www.ncbi.nlm.nih.gov/pubmed/28531964
http://dx.doi.org/10.1016/j.redox.2017.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440747/
https://www.ncbi.nlm.nih.gov/pubmed/28531964
http://dx.doi.org/10.1016/j.redox.2017.05.003

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