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Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription
Mitochondria are the main consumers of molecular O(2) in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α). While a number of mechanisms in the oxygen-dependent HIF-α regula...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440747/ https://www.ncbi.nlm.nih.gov/pubmed/28531964 http://dx.doi.org/10.1016/j.redox.2017.05.003 |