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An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

The non-receptor tyrosine kinase Src is a key signalling hub for upregulating the function of N-methyl D-aspartate receptors (NMDARs). Src is anchored within the NMDAR complex via NADH dehydrogenase subunit 2 (ND2), a mitochondrially encoded adaptor protein. The interacting regions between Src and N...

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Detalles Bibliográficos
Autores principales: Scanlon, David P., Bah, Alaji, Krzeminski, Mickaël, Zhang, Wenbo, Leduc-Pessah, Heather L., Dong, Yi Na, Forman-Kay, Julie D., Salter, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440837/
https://www.ncbi.nlm.nih.gov/pubmed/28508887
http://dx.doi.org/10.1038/ncomms15220