Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis

Hepatocellular carcinoma (HCC), a primary malignancy of the liver, is the second leading cause of cancer mortality worldwide. Fibroblast Growth Factor 19 (FGF19) is one of the most frequently amplified genes in HCC patients. Moreover, mice expressing an FGF19 transgene have been shown to develop HCC...

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Detalles Bibliográficos
Autores principales: Zhou, Mei, Yang, Hong, Learned, R. Marc, Tian, Hui, Ling, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440856/
https://www.ncbi.nlm.nih.gov/pubmed/28508871
http://dx.doi.org/10.1038/ncomms15433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440856/
https://www.ncbi.nlm.nih.gov/pubmed/28508871
http://dx.doi.org/10.1038/ncomms15433

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