Cargando…

Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial

BACKGROUND: Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely prescribed phosphodiesterase-5 inhibitor that increases blood flow in other vascular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pauls, Mathilde M. H., Clarke, Natasha, Trippier, Sarah, Betteridge, Shai, Howe, Franklyn A., Khan, Usman, Kruuse, Christina, Madigan, Jeremy B., Moynihan, Barry, Pereira, Anthony C., Rolfe, Debbie, Rostrup, Egill, Haig, Caroline E., Barrick, Thomas R., Isaacs, Jeremy D., Hainsworth, Atticus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440904/ https://www.ncbi.nlm.nih.gov/pubmed/28532471 http://dx.doi.org/10.1186/s13063-017-1973-9

Ejemplares similares

Testing the cognitive effects of tadalafil. Neuropsychological secondary outcomes from the PASTIS trial
por: Pauls, Mathilde MH, et al.
Publicado: (2023)

The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment
por: Pauls, Mathilde M.H., et al.
Publicado: (2022)

The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review
por: Pauls, Mathilde MH, et al.
Publicado: (2017)

Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease
por: Binnie, Lauren R., et al.
Publicado: (2022)

Tadalafil may improve cerebral perfusion in small-vessel occlusion stroke—a pilot study
por: Ölmestig, Joakim, et al.
Publicado: (2020)

Bier and Pastis, a pixel readout prototype chip for LHC
por: Berg, C, et al.
Publicado: (2000)

PDE5 inhibitor drugs for use in dementia
por: Hainsworth, Atticus H., et al.
Publicado: (2023)

Strokectomy for malignant middle cerebral artery infarction: experience and meta-analysis of current evidence
por: Moughal, Saad, et al.
Publicado: (2020)

Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries –relevant to migraine?
por: Kruuse, Christina, et al.
Publicado: (2011)

Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation
por: Golenser, Jacob, et al.
Publicado: (2020)

A single dose of exenatide had no effect on blood flow velocity in the middle cerebral artery in elderly healthy volunteers: Randomized, placebo-controlled, double-blind clinical trial
por: Ölmestig, Joakim, et al.
Publicado: (2022)

Altered somatosensory neurovascular response in patients with Becker muscular dystrophy
por: Lindberg, Ulrich, et al.
Publicado: (2018)

Home-based aerobic exercise in patients with lacunar stroke: Design of the HITPALS randomized controlled trial
por: Steen Krawcyk, Rikke, et al.
Publicado: (2019)

Optimization of quasi‐diffusion magnetic resonance imaging for quantitative accuracy and time‐efficient acquisition
por: Spilling, Catherine A., et al.
Publicado: (2022)

M148. NORMALIZATION IN REWARD PROCESSING DURING INITIAL TREATMENT MAY PREDICT LONG-TERM CLINICAL OUTCOME IN ANTIPSYCHOTIC NAïVE SCHIZOPHRENIA PATIENTS
por: Nielsen, Mette, et al.
Publicado: (2020)

The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension
por: Falk, Jeremy A, et al.
Publicado: (2010)

Reduced anterior cingulate grey matter volume in painful hand osteoarthritis
por: Russell, Mark D., et al.
Publicado: (2018)

Tadalafil in the treatment of erectile dysfunction
por: Coward, Robert M, et al.
Publicado: (2008)

Myopathy with Concurrent Tadalafil and Simvastatin
por: Gargante, Maria Pia, et al.
Publicado: (2009)

An introduction to therapeutic approaches to vascular cognitive impairment
por: Hainsworth, Atticus H, et al.
Publicado: (2021)

Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil Databases
por: Brock, Gerald, et al.
Publicado: (2016)

Effect of Home-Based High-Intensity Interval Training in Patients With Lacunar Stroke: A Randomized Controlled Trial
por: Steen Krawcyk, Rikke, et al.
Publicado: (2019)

Central Serous Chorioretinopathy Associated with Tadalafil
por: Alsarhani, Abdulaziz, et al.
Publicado: (2022)

Vasculocentric Axonal NfH in Small Vessel Disease
por: Anad, Adam, et al.
Publicado: (2022)

Role of Ser102 and Ser104 as Regulators of cGMP Hydrolysis by PDE5A
por: Carøe Nordgaard, Julie, et al.
Publicado: (2014)

PAin SoluTions In the Emergency Setting (PASTIES)—patient controlled analgesia versus routine care in emergency department patients with pain from traumatic injuries: randomised trial
por: Smith, Jason E, et al.
Publicado: (2015)

PAin SoluTions In the Emergency Setting (PASTIES)—patient controlled analgesia versus routine care in emergency department patients with non-traumatic abdominal pain: randomised trial
por: Smith, Jason E, et al.
Publicado: (2015)

Tissue-type mapping of gliomas
por: Raschke, Felix, et al.
Publicado: (2018)

Meta-Analysis of the Long-Term Efficacy and Tolerance of Tadalafil Daily Compared With Tadalafil On-Demand in Treating Men With Erectile Dysfunction
por: Zhou, Zhongbao, et al.
Publicado: (2019)

The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats
por: Shen, Xiuwei, et al.
Publicado: (2020)

Effects of sildenafil and tadalafil on skin flap viability
por: Souza, Rafael A. C., et al.
Publicado: (2021)

PAin SoluTions In the Emergency Setting (PASTIES); a protocol for two open-label randomised trials of patient-controlled analgesia (PCA) versus routine care in the emergency department
por: Smith, Jason E, et al.
Publicado: (2013)

Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)
por: Hassel, Jessica C., et al.
Publicado: (2017)

Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction
por: Mohamed, Soad A., et al.
Publicado: (2023)

Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction
por: Jang, Se Won, et al.
Publicado: (2022)

Brain tumor classification using the diffusion tensor image segmentation (D-SEG) technique
por: Jones, Timothy L., et al.
Publicado: (2015)

Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model
por: Kauschke, Vivien, et al.
Publicado: (2018)

Meta-Analysis of Efficacy and Safety of Tadalafil Plus Tamsulosin Compared with Tadalafil Alone in Treating Men with Benign Prostatic Hyperplasia and Erectile Dysfunction
por: Zhou, Zhongbao, et al.
Publicado: (2019)

Correction: Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction
por: Jang, Se Won, et al.
Publicado: (2022)

Efficacy of tadalafil in Egyptian and Turkish men with erectile dysfunction
por: ŞAYLAN, M, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_qalpakmeo6uqlkn4nfnms961nj