Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma

OBJECTIVE: To investigate the potential association of neutrophil-to-lymphocyte ratio (NLR), a surrogate systemic inflammatory biomarker, with clinical and pathological characteristics of papillary thyroid cancers. METHODS: 205 patients with papillary carcinoma were identified from the institutional...

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Autores principales: Manatakis, Dimitrios K., Tseleni-Balafouta, Sofia, Balalis, Dimitrios, Soulou, Vasiliki N., Korkolis, Dimitrios P., Sakorafas, George H., Plataniotis, Georgios, Gontikakis, Emmanouil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441114/
https://www.ncbi.nlm.nih.gov/pubmed/28572821
http://dx.doi.org/10.1155/2017/8471235
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author Manatakis, Dimitrios K.
Tseleni-Balafouta, Sofia
Balalis, Dimitrios
Soulou, Vasiliki N.
Korkolis, Dimitrios P.
Sakorafas, George H.
Plataniotis, Georgios
Gontikakis, Emmanouil
author_facet Manatakis, Dimitrios K.
Tseleni-Balafouta, Sofia
Balalis, Dimitrios
Soulou, Vasiliki N.
Korkolis, Dimitrios P.
Sakorafas, George H.
Plataniotis, Georgios
Gontikakis, Emmanouil
author_sort Manatakis, Dimitrios K.
collection PubMed
description OBJECTIVE: To investigate the potential association of neutrophil-to-lymphocyte ratio (NLR), a surrogate systemic inflammatory biomarker, with clinical and pathological characteristics of papillary thyroid cancers. METHODS: 205 patients with papillary carcinoma were identified from the institutional thyroid cancer database between 2006 and 2015 (55 males, 150 females, mean age 51.2 ± 14.7 years). NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count, based on the preoperative complete blood cell counts. RESULTS: NLR was significantly higher in carcinomas with extrathyroidal invasion (2.74 ± 01.24 versus 2.39 ± 0.96, p = 0.04) and bilateral (2.67 ± 1.15 versus 2.35 ± 0.96, p = 0.03) and multifocal tumours (2.65 ± 1.08 versus 2.29 ± 0.96, p = 0.01), as well as lymph node-positive tumours (3.12 ± 1.07 versus 2.41 ± 1.02, p = 0.03). On the other hand, NLR values were not associated with gender, age, tumour size, histologic subtype, the presence of thyroiditis, and TNM staging. CONCLUSIONS: As an index of inflammation, NLR is inexpensive, readily available, and easy to extract from routine blood tests. We found increased NLR values in papillary carcinomas with poorer histopathological profile and more aggressive clinical behaviour. Whether this systemic inflammatory response, as expressed by the NLR, represents the inflammatory microenvironment leading to tumourigenesis, or is a tumour-associated phenomenon, remains to be elucidated and warrants further study.
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spelling pubmed-54411142017-06-01 Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma Manatakis, Dimitrios K. Tseleni-Balafouta, Sofia Balalis, Dimitrios Soulou, Vasiliki N. Korkolis, Dimitrios P. Sakorafas, George H. Plataniotis, Georgios Gontikakis, Emmanouil Int J Endocrinol Research Article OBJECTIVE: To investigate the potential association of neutrophil-to-lymphocyte ratio (NLR), a surrogate systemic inflammatory biomarker, with clinical and pathological characteristics of papillary thyroid cancers. METHODS: 205 patients with papillary carcinoma were identified from the institutional thyroid cancer database between 2006 and 2015 (55 males, 150 females, mean age 51.2 ± 14.7 years). NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count, based on the preoperative complete blood cell counts. RESULTS: NLR was significantly higher in carcinomas with extrathyroidal invasion (2.74 ± 01.24 versus 2.39 ± 0.96, p = 0.04) and bilateral (2.67 ± 1.15 versus 2.35 ± 0.96, p = 0.03) and multifocal tumours (2.65 ± 1.08 versus 2.29 ± 0.96, p = 0.01), as well as lymph node-positive tumours (3.12 ± 1.07 versus 2.41 ± 1.02, p = 0.03). On the other hand, NLR values were not associated with gender, age, tumour size, histologic subtype, the presence of thyroiditis, and TNM staging. CONCLUSIONS: As an index of inflammation, NLR is inexpensive, readily available, and easy to extract from routine blood tests. We found increased NLR values in papillary carcinomas with poorer histopathological profile and more aggressive clinical behaviour. Whether this systemic inflammatory response, as expressed by the NLR, represents the inflammatory microenvironment leading to tumourigenesis, or is a tumour-associated phenomenon, remains to be elucidated and warrants further study. Hindawi 2017 2017-05-09 /pmc/articles/PMC5441114/ /pubmed/28572821 http://dx.doi.org/10.1155/2017/8471235 Text en Copyright © 2017 Dimitrios K. Manatakis et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Manatakis, Dimitrios K.
Tseleni-Balafouta, Sofia
Balalis, Dimitrios
Soulou, Vasiliki N.
Korkolis, Dimitrios P.
Sakorafas, George H.
Plataniotis, Georgios
Gontikakis, Emmanouil
Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
title Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
title_full Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
title_fullStr Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
title_full_unstemmed Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
title_short Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
title_sort association of baseline neutrophil-to-lymphocyte ratio with clinicopathological characteristics of papillary thyroid carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441114/
https://www.ncbi.nlm.nih.gov/pubmed/28572821
http://dx.doi.org/10.1155/2017/8471235
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