Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening

[Image: see text] Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Despite the extensive efforts in targeting the ubiquitin system, very few E2 binder...

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Detalles Bibliográficos
Autores principales: Morreale, Francesca E., Bortoluzzi, Alessio, Chaugule, Viduth K., Arkinson, Connor, Walden, Helen, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441753/
https://www.ncbi.nlm.nih.gov/pubmed/28437106
http://dx.doi.org/10.1021/acs.jmedchem.7b00147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441753/
https://www.ncbi.nlm.nih.gov/pubmed/28437106
http://dx.doi.org/10.1021/acs.jmedchem.7b00147

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