Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops

Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. Genetic analysis identified the Srs2 helicase as a pri...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Ede, Christopher, Wright, William D, Gore, Steven K, Jenkins, Shirin S, Freudenthal, Bret D, Todd Washington, M, Veaute, Xavier, Heyer, Wolf-Dietrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441872/
https://www.ncbi.nlm.nih.gov/pubmed/28535142
http://dx.doi.org/10.7554/eLife.22195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441872/
https://www.ncbi.nlm.nih.gov/pubmed/28535142
http://dx.doi.org/10.7554/eLife.22195

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