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Symmetry‐breaking in branching epithelia: cells on micro‐patterns under flow challenge the hypothesis of positive feedback by a secreted autocrine inhibitor of motility

Branching morphogenesis of epithelia involves division of cells into leader (tip) and follower (stalk) cells. Published work on cell lines in culture has suggested that symmetry‐breaking takes place via a secreted autocrine inhibitor of motility, the inhibitor accumulating more in concave regions of...

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Detalles Bibliográficos
Autores principales: Martin, Kimberly C., Yuan, Xiaofei, Stimac, Gregory, Bannerman, Kieran, Anderson, Jamie, Roy, Chloe, Glykofrydis, Fokion, Yin, Huabing, Davies, Jamie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442143/
https://www.ncbi.nlm.nih.gov/pubmed/28369863
http://dx.doi.org/10.1111/joa.12599