GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. Herein, we identified HIV-1 integrase as a previously unknown substrate of GCN2 in vitro wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Jaspart, A., Calmels, C., Cosnefroy, O., Bellecave, P., Pinson, P., Claverol, S., Guyonnet-Dupérat, V., Dartigues, B., Benleulmi, M. S., Mauro, E., Gretteau, P. A., Parissi, V., Métifiot, M., Andreola, M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442153/
https://www.ncbi.nlm.nih.gov/pubmed/28536474
http://dx.doi.org/10.1038/s41598-017-02276-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442153/
https://www.ncbi.nlm.nih.gov/pubmed/28536474
http://dx.doi.org/10.1038/s41598-017-02276-0

Ejemplares similares