Cargando…

GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. Herein, we identified HIV-1 integrase as a previously unknown substrate of GCN2 in vitro wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaspart, A., Calmels, C., Cosnefroy, O., Bellecave, P., Pinson, P., Claverol, S., Guyonnet-Dupérat, V., Dartigues, B., Benleulmi, M. S., Mauro, E., Gretteau, P. A., Parissi, V., Métifiot, M., Andreola, M. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442153/ https://www.ncbi.nlm.nih.gov/pubmed/28536474 http://dx.doi.org/10.1038/s41598-017-02276-0

Ejemplares similares

In vitro initial attachment of HIV-1 integrase to viral ends: control of the DNA specific interaction by the oligomerization state
por: Lesbats, P., et al.
Publicado: (2008)

The HIV-1 Integrase Mutations Y143C/R Are an Alternative Pathway for Resistance to Raltegravir and Impact the Enzyme Functions
por: Reigadas, Sandrine, et al.
Publicado: (2010)

HIV-1 integrase crosslinked oligomers are active in vitro
por: Faure, Aurélie, et al.
Publicado: (2005)

Targeting the Integrated Stress Response Kinase GCN2 to Modulate Retroviral Integration
por: Torres, Chloé, et al.
Publicado: (2021)

Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51
por: Desfarges, S., et al.
Publicado: (2006)

Functional Coupling between HIV-1 Integrase and the SWI/SNF Chromatin Remodeling Complex for Efficient in vitro Integration into Stable Nucleosomes
por: Lesbats, Paul, et al.
Publicado: (2011)

Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75
por: Lapaillerie, Delphine, et al.
Publicado: (2021)

DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity
por: Naughtin, Monica, et al.
Publicado: (2015)

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration
por: Matysiak, Julien, et al.
Publicado: (2017)

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration
por: Terreni, Mariaelena, et al.
Publicado: (2010)

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration
por: Terreni, Mariaelena, et al.
Publicado: (2009)

Natural Stilbenoids Isolated from Grapevine Exhibiting Inhibitory Effects against HIV-1 Integrase and Eukaryote MOS1 Transposase In Vitro Activities
por: Pflieger, Aude, et al.
Publicado: (2013)

Small-angle X-ray characterization of the nucleoprotein complexes resulting from DNA-induced oligomerization of HIV-1 integrase
por: Baranova, Svetlana, et al.
Publicado: (2007)

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases
por: Zhao, Xue Zhi, et al.
Publicado: (2016)

Investigation of anti-HIV activity, cytotoxicity and HIV integrase inhibitory activity of polyherbal formulation BH extracts
por: Balraj, S, et al.
Publicado: (2014)

The C-Terminal Domain of HIV-1 Integrase: A Swiss Army Knife for the Virus?
por: Rocchi, Cecilia, et al.
Publicado: (2022)

Absence of Resistance Mutations in the Integrase Coding Region among ART-Experienced Patients in the Republic of the Congo
por: Got, Ferdinand Emaniel Brel, et al.
Publicado: (2021)

Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails
por: Benleulmi, Mohamed S., et al.
Publicado: (2017)

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors
por: Zhao, Xue Zhi, et al.
Publicado: (2017)

Integrase and integration: biochemical activities of HIV-1 integrase
por: Delelis, Olivier, et al.
Publicado: (2008)

Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening
por: Aknin, Cindy, et al.
Publicado: (2019)

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence
por: Zhao, Xue Zhi, et al.
Publicado: (2018)

De novo RNA synthesis catalyzed by the Zika Virus RNA polymerase domain
por: Calmels, Christina, et al.
Publicado: (2017)

Efficient and Specific Internal Cleavage of a Retroviral Palindromic DNA Sequence by Tetrameric HIV-1 Integrase
por: Delelis, Olivier, et al.
Publicado: (2007)

Bicyclic 1-Hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-Containing HIV-1 Integrase Inhibitors Having High Antiviral Potency against Cells Harboring Raltegravir-Resistant Integrase Mutants
por: Zhao, Xue Zhi, et al.
Publicado: (2014)

Multimodal Functionalities of HIV-1 Integrase
por: Engelman, Alan N., et al.
Publicado: (2022)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
por: Koneru, Pratibha C, et al.
Publicado: (2019)

Resistance to Integrase Inhibitors
por: Métifiot, Mathieu, et al.
Publicado: (2010)

Consensus Integrase of a New HIV-1 Genetic Variant CRF63_02A1
por: Agapkina, Y. Y., et al.
Publicado: (2019)

Characterization of natural polymorphic sites of the HIV-1 integrase before the introduction of HIV-1 integrase inhibitors in Germany
por: Meixenberger, Karolin, et al.
Publicado: (2014)

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import
por: Cribier, Alexandra, et al.
Publicado: (2011)

Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins
por: Corvaglia, Valentina, et al.
Publicado: (2019)

The HIV-1 Integrase α4-Helix Involved in LTR-DNA Recognition Is also a Highly Antigenic Peptide Element
por: Azzi, Sandy, et al.
Publicado: (2010)

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
por: Rhee, Soo-Yon, et al.
Publicado: (2016)

HIV-1 Integrase-DNA Recognition Mechanisms
por: Kessl, Jacques J., et al.
Publicado: (2009)

HIV-1 integrase SUMOylation and viral replication
por: Zamborlini, Alessia, et al.
Publicado: (2011)

Structural-Functional Analysis of 2,1,3-Benzoxadiazoles and Their N-oxides As HIV-1 Integrase Inhibitors
por: Korolev, S. P., et al.
Publicado: (2013)

Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration
por: Thierry, Sylvain, et al.
Publicado: (2015)

Relative Comparison of Catalytic Characteristics of Human Foamy Virus and HIV-1 Integrases
por: Knyazhanskaya, E. S., et al.
Publicado: (2009)

Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase
por: Mauro, Eric, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1jt6alqlk76r1p4j9epm9m9v0e