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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

Complement C1 is the defining component of the classical pathway. Within the C1qC1r(2)C1s(2) complex, C1q functions as a molecular scaffold for C1r(2)C1s(2) and C1q binding to its ligands activates these two serine proteases. The classic C1q ligands are antigen-bound antibodies and activated C1s cle...

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Detalles Bibliográficos
Autores principales: Lu, Jinhua, Kishore, Uday
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442170/
https://www.ncbi.nlm.nih.gov/pubmed/28596769
http://dx.doi.org/10.3389/fimmu.2017.00592