The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms

Spinal and bulbar muscular atrophy (SBMA) is caused by expression of a polyglutamine (polyQ)-expanded androgen receptor (AR). The inefficient nuclear proteasomal degradation of the mutant AR results in the formation of nuclear inclusions containing amino-terminal fragments of the mutant AR. PA28γ (a...

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Detalles Bibliográficos
Autores principales: Yersak, Jill M., Montie, Heather L., Chevalier-Larsen, Erica S., Liu, Yuhong, Huang, Lan, Rechsteiner, Martin, Merry, Diane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442185/
https://www.ncbi.nlm.nih.gov/pubmed/28596723
http://dx.doi.org/10.3389/fnmol.2017.00159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442185/
https://www.ncbi.nlm.nih.gov/pubmed/28596723
http://dx.doi.org/10.3389/fnmol.2017.00159

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