Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners

Neuropathic pain is relatively less responsive to opioids than other types of pain, which is possibly due to a disrupted opioid system partially caused by the profound microglial cell activation that underlines neuroinflammation. We demonstrated that intrathecally injected biphalin, a dimeric enkeph...

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Detalles Bibliográficos
Autores principales: Popiolek-Barczyk, Katarzyna, Piotrowska, Anna, Makuch, Wioletta, Mika, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442438/
https://www.ncbi.nlm.nih.gov/pubmed/28573049
http://dx.doi.org/10.1155/2017/3829472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442438/
https://www.ncbi.nlm.nih.gov/pubmed/28573049
http://dx.doi.org/10.1155/2017/3829472

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