Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway

Keratins (K) are intermediate filament proteins important in stress protection and mechanical support of epithelial tissues. K8, K18 and K19 are the main colonic keratins, and K8-knockout (K8(−/−)) mice display a keratin dose-dependent hyperproliferation of colonic crypts and a colitis-phenotype. Ho...

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Detalles Bibliográficos
Autores principales: Lähdeniemi, Iris A K, Misiorek, Julia O, Antila, Christian J M, Landor, Sebastian K-J, Stenvall, Carl-Gustaf A, Fortelius, Lina E, Bergström, Linda K, Sahlgren, Cecilia, Toivola, Diana M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442467/
https://www.ncbi.nlm.nih.gov/pubmed/28475172
http://dx.doi.org/10.1038/cdd.2017.28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442467/
https://www.ncbi.nlm.nih.gov/pubmed/28475172
http://dx.doi.org/10.1038/cdd.2017.28

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