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Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke

Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidati...

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Autores principales: Belayev, Ludmila, Mukherjee, Pranab K, Balaszczuk, Veronica, Calandria, Jorgelina M, Obenaus, Andre, Khoutorova, Larissa, Hong, Sung-Ha, Bazan, Nicolas G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442474/
https://www.ncbi.nlm.nih.gov/pubmed/28430183
http://dx.doi.org/10.1038/cdd.2017.55
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author Belayev, Ludmila
Mukherjee, Pranab K
Balaszczuk, Veronica
Calandria, Jorgelina M
Obenaus, Andre
Khoutorova, Larissa
Hong, Sung-Ha
Bazan, Nicolas G
author_facet Belayev, Ludmila
Mukherjee, Pranab K
Balaszczuk, Veronica
Calandria, Jorgelina M
Obenaus, Andre
Khoutorova, Larissa
Hong, Sung-Ha
Bazan, Nicolas G
author_sort Belayev, Ludmila
collection PubMed
description Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidative stress (UOS). Our data demonstrate that NPD1 potently upregulates Iduna expression and provides remarkable cell protection against UOS. Iduna, which was increased by the lipid mediator, requires the presence of the poly(ADP-ribose) (PAR) sites. Moreover, astrocytes and neurons in the penumbra display an enhanced abundance of Iduna, followed by remarkable neurological protection when DHA, a precursor of NPD1, is systemically administered 1 h after 2 h of ischemic stroke. These findings provide a conceptual advancement for survival of neural cells undergoing challenges to homeostasis because a lipid mediator, made 'on demand,' modulates the abundance of a critically important protein for cell survival.
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spelling pubmed-54424742017-06-03 Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke Belayev, Ludmila Mukherjee, Pranab K Balaszczuk, Veronica Calandria, Jorgelina M Obenaus, Andre Khoutorova, Larissa Hong, Sung-Ha Bazan, Nicolas G Cell Death Differ Original Paper Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidative stress (UOS). Our data demonstrate that NPD1 potently upregulates Iduna expression and provides remarkable cell protection against UOS. Iduna, which was increased by the lipid mediator, requires the presence of the poly(ADP-ribose) (PAR) sites. Moreover, astrocytes and neurons in the penumbra display an enhanced abundance of Iduna, followed by remarkable neurological protection when DHA, a precursor of NPD1, is systemically administered 1 h after 2 h of ischemic stroke. These findings provide a conceptual advancement for survival of neural cells undergoing challenges to homeostasis because a lipid mediator, made 'on demand,' modulates the abundance of a critically important protein for cell survival. Nature Publishing Group 2017-06 2017-04-21 /pmc/articles/PMC5442474/ /pubmed/28430183 http://dx.doi.org/10.1038/cdd.2017.55 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Paper
Belayev, Ludmila
Mukherjee, Pranab K
Balaszczuk, Veronica
Calandria, Jorgelina M
Obenaus, Andre
Khoutorova, Larissa
Hong, Sung-Ha
Bazan, Nicolas G
Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_full Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_fullStr Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_full_unstemmed Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_short Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
title_sort neuroprotectin d1 upregulates iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442474/
https://www.ncbi.nlm.nih.gov/pubmed/28430183
http://dx.doi.org/10.1038/cdd.2017.55
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