Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell‐Derived Platelets

Donor‐independent platelet concentrates for transfusion can be produced in vitro from induced pluripotent stem cells (iPSCs). However, culture at 37°C induces ectodomain shedding on platelets of glycoprotein Ibα (GPIbα), the von Willebrand factor receptor critical for adhesive function and platelet...

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Detalles Bibliográficos
Autores principales: Hirata, Shinji, Murata, Takahiko, Suzuki, Daisuke, Nakamura, Sou, Jono‐Ohnishi, Ryoko, Hirose, Hidenori, Sawaguchi, Akira, Nishimura, Satoshi, Sugimoto, Naoshi, Eto, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Translational Research Articles and Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442763/
https://www.ncbi.nlm.nih.gov/pubmed/28297575
http://dx.doi.org/10.5966/sctm.2016-0104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442763/
https://www.ncbi.nlm.nih.gov/pubmed/28297575
http://dx.doi.org/10.5966/sctm.2016-0104

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