Cargando…

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno‐Free Conditions Restore Motor Deficits in Parkinsonian Rodents

Recent studies have shown evidence for the functional integration of human pluripotent stem cell (hPSC)‐derived ventral midbrain dopamine (vmDA) neurons in animal models of Parkinson’s disease. Although these cells present a sustainable alternative to fetal mesencephalic grafts, a number of hurdles...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niclis, Jonathan C., Gantner, Carlos W., Alsanie, Walaa F., McDougall, Stuart J., Bye, Chris R., Elefanty, Andrew G., Stanley, Edouard G., Haynes, John M., Pouton, Colin W., Thompson, Lachlan H., Parish, Clare L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Translational Research Articles and Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442782/ https://www.ncbi.nlm.nih.gov/pubmed/28297587 http://dx.doi.org/10.5966/sctm.2016-0073

Ejemplares similares

Specification of murine ground state pluripotent stem cells to regional neuronal populations
por: Alsanie, Walaa F., et al.
Publicado: (2017)

Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways
por: Alsanie, W. F., et al.
Publicado: (2017)

FGF-MAPK signaling regulates human deep-layer corticogenesis
por: Gantner, Carlos W., et al.
Publicado: (2021)

An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions
por: Gantner, Carlos W., et al.
Publicado: (2020)

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells
por: Niclis, Jonathan C., et al.
Publicado: (2017)

Prenatal Exposure to Gabapentin Alters the Development of Ventral Midbrain Dopaminergic Neurons
por: Alsanie, Walaa F., et al.
Publicado: (2022)

The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons
por: Alsanie, Walaa F., et al.
Publicado: (2022)

The Influence of Prenatal Exposure to Methamphetamine on the Development of Dopaminergic Neurons in the Ventral Midbrain
por: Alsanie, Walaa F., et al.
Publicado: (2023)

The Influence of Prenatal Exposure to Quetiapine Fumarate on the Development of Dopaminergic Neurons in the Ventral Midbrain of Mouse Embryos
por: Alsanie, Walaa F., et al.
Publicado: (2022)

Protocol for generating reproducible miniaturized controlled midbrain organoids
por: Chen, Muwan, et al.
Publicado: (2023)

DNA-Dependent Protein Kinase Is a Context Dependent Regulator of Lmx1a and Midbrain Specification
por: Hunt, Cameron P., et al.
Publicado: (2013)

Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines
por: Niclis, Jonathan C., et al.
Publicado: (2013)

Linear ensemble-coding in midbrain superior colliculus specifies the saccade kinematics
por: van Opstal, A. J., et al.
Publicado: (2008)

Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates
por: Bridi, Jessika C., et al.
Publicado: (2020)

Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain
por: Bye, Christopher R., et al.
Publicado: (2019)

Neural signals of extinction in the inhibitory microcircuit of the ventral midbrain
por: Pan, Wei-Xing, et al.
Publicado: (2012)

Methamphetamine regulation of activity and topology of ventral midbrain networks
por: Miller, Douglas R., et al.
Publicado: (2019)

Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain
por: Hui, May, et al.
Publicado: (2022)

Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
por: Vissani, Matteo, et al.
Publicado: (2022)

Dissociable Reward and Timing Signals in Human Midbrain and Ventral Striatum
por: Klein-Flügge, Miriam C., et al.
Publicado: (2011)

Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis
por: Ribeiro, Diogo, et al.
Publicado: (2011)

Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development
por: Tang, Mianzhi, et al.
Publicado: (2013)

Defensive Behaviors Driven by a Hypothalamic-Ventral Midbrain Circuit
por: Mangieri, Leandra R., et al.
Publicado: (2019)

Enhanced representation of natural sound sequences in the ventral auditory midbrain
por: González-Palomares, Eugenia, et al.
Publicado: (2020)

Human‐Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons
por: Monzón‐Sandoval, Jimena, et al.
Publicado: (2020)

Divergent Whole Brain Projections from the Ventral Midbrain in Macaques
por: Zubair, Muhammad, et al.
Publicado: (2021)

Differential expression of the adult specifier E93 in the strepsipteran Xenos vesparum Rossi suggests a role in female neoteny
por: Chafino, S., et al.
Publicado: (2018)

Wnt5a Regulates Midbrain Dopaminergic Axon Growth and Guidance
por: Blakely, Brette D., et al.
Publicado: (2011)

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
por: Stamatakis, Alice M., et al.
Publicado: (2012)

Ventral midbrain stimulation induces perceptual learning and cortical plasticity in primates
por: Arsenault, John T., et al.
Publicado: (2019)

Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes
por: Han, Jin Yi, et al.
Publicado: (2023)

Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons
por: Zhu, Xinyu, et al.
Publicado: (2023)

Human pluripotent stem cell derived midbrain PITX3(eGFP/w) neurons: a versatile tool for pharmacological screening and neurodegenerative modeling
por: Watmuff, Bradley, et al.
Publicado: (2015)

Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration
por: Theofilopoulos, Spyridon, et al.
Publicado: (2015)

Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation
por: Hernandez, Giovanni, et al.
Publicado: (2016)

Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations
por: Nakamura, Yuko, et al.
Publicado: (2018)

A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys
por: Suzuki, Michiaki, et al.
Publicado: (2022)

Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain
por: Hobson, Benjamin D., et al.
Publicado: (2023)

AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression
por: Hang, Liting, et al.
Publicado: (2018)

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
por: Hedlund, Eva, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dghrhn8cq3gb1v26v8vgi9glil