Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what's important?

Pre-existing immunity against human adenovirus (HAd) serotype 5 derived vector in the human population is widespread, thus hampering its clinical use. Various components of the immune system, including neutralizing antibodies (nAbs), Ad specific T cells and type I IFN activated NK cells, contribute...

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Detalles Bibliográficos
Autores principales: Fausther-Bovendo, Hugues, Kobinger, Gary P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443060/
https://www.ncbi.nlm.nih.gov/pubmed/25483662
http://dx.doi.org/10.4161/hv.29594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443060/
https://www.ncbi.nlm.nih.gov/pubmed/25483662
http://dx.doi.org/10.4161/hv.29594

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