Binding of CIB1 to the α(IIb) tail of α(IIb)β(3) is required for FAK recruitment and activation in platelets

BACKGROUND: It is believed that activation of c-Src bound to the integrin β(3) subunit initiates outside-in signaling. The involvement of α(IIb) in outside-in signaling is poorly understood. OBJECTIVES: We have previously shown that CIB1 specifically interacts with the cytoplasmic domain of α(IIb) a...

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Detalles Bibliográficos
Autores principales: Naik, Meghna U., Naik, Tejal U., Summer, Ross, Naik, Ulhas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443481/
https://www.ncbi.nlm.nih.gov/pubmed/28542214
http://dx.doi.org/10.1371/journal.pone.0176602

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