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Novel AgoshRNA molecules for silencing of the CCR5 co-receptor for HIV-1 infection
Allogeneic transplantation of blood stem cells from a CCR5-Δ32 homozygous donor to an HIV-infected individual, the “Berlin patient”, led to a cure. Since then there has been a search for approaches that mimic this intervention in a gene therapy setting. RNA interference (RNAi) has evolved as a power...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443530/ https://www.ncbi.nlm.nih.gov/pubmed/28542329 http://dx.doi.org/10.1371/journal.pone.0177935 |