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Novel AgoshRNA molecules for silencing of the CCR5 co-receptor for HIV-1 infection

Allogeneic transplantation of blood stem cells from a CCR5-Δ32 homozygous donor to an HIV-infected individual, the “Berlin patient”, led to a cure. Since then there has been a search for approaches that mimic this intervention in a gene therapy setting. RNA interference (RNAi) has evolved as a power...

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Detalles Bibliográficos
Autores principales: Herrera-Carrillo, Elena, Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443530/
https://www.ncbi.nlm.nih.gov/pubmed/28542329
http://dx.doi.org/10.1371/journal.pone.0177935

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