Cargando…

The human asparaginase enzyme (ASPG) inhibits growth in leukemic cells

The human protein ASPG is an enzyme with a putative antitumor activity. We generated in bacteria and then purified a recombinant GST-ASPG protein that we used to characterize the biochemical and cytotoxic properties of the human ASPG. We demonstrated that ASPG possesses asparaginase and PAF acetylhy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Belviso, Stefania, Iuliano, Rodolfo, Amato, Rosario, Perrotti, Nicola, Menniti, Miranda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443537/ https://www.ncbi.nlm.nih.gov/pubmed/28542249 http://dx.doi.org/10.1371/journal.pone.0178174

Ejemplares similares

New SLC12A3 disease causative mutation of Gitelman’s syndrome
por: Grillone, Teresa, et al.
Publicado: (2016)

Overexpression of the aspartic protease ASPG1 gene confers drought avoidance in Arabidopsis
por: Yao, Xuan, et al.
Publicado: (2012)

Masquerade of Leukemic Infiltration With Cerebral Sinus Venous Thrombosis Causing Papilledema by Asparaginase Therapy
por: Abumohssin, Abdulelah G, et al.
Publicado: (2023)

A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis
por: Bilotta, Anna, et al.
Publicado: (2016)

Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian Sea
por: Sobat, Motahareh, et al.
Publicado: (2021)

RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases
por: Audia, Salvatore, et al.
Publicado: (2023)

Kinase Inhibitors in Genetic Diseases
por: D’Antona, Lucia, et al.
Publicado: (2023)

SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation
por: Dattilo, Vincenzo, et al.
Publicado: (2017)

RANBP1, a member of the nuclear-cytoplasmic trafficking-regulator complex, is the terminal-striking point of the SGK1-dependent Th17(+) pathological differentiation
por: Brescia, Carolina, et al.
Publicado: (2023)

In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity
por: D'Antona, Lucia, et al.
Publicado: (2019)

Germline Testing in a Cohort of Patients at High Risk of Hereditary Cancer Predisposition Syndromes: First Two-Year Results from South Italy
por: Paduano, Francesco, et al.
Publicado: (2022)

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells
por: Talarico, Cristina, et al.
Publicado: (2016)

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

Cell-Cycle Inhibition by Helicobacter pylori L-Asparaginase
por: Scotti, Claudia, et al.
Publicado: (2010)

Bioprocess Optimization of Nutritional Parameters for Enhanced Anti-leukemic L-Asparaginase Production by Aspergillus candidus UCCM 00117: A Sequential Statistical Approach
por: Ekpenyong, Maurice, et al.
Publicado: (2021)

The Role of MicroRNAs in Cancer Susceptibility
por: Iuliano, Rodolfo, et al.
Publicado: (2013)

The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms
por: Dattilo, Vincenzo, et al.
Publicado: (2020)

Th17-Gene Expression Profile in Patients with Chronic Venous Disease and Venous Ulcers: Genetic Modulations and Preliminary Clinical Evidence
por: Amato, Rosario, et al.
Publicado: (2022)

A Familial Form of Epidermolysis Bullosa Simplex Associated with a Pathogenic Variant in KRT5
por: Paduano, Francesco, et al.
Publicado: (2021)

Correction: Cell-Cycle Inhibition by Helicobacter pylori L-Asparaginase
por: Scotti, Claudia, et al.
Publicado: (2012)

Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity
por: Costa, Iris Munhoz, et al.
Publicado: (2016)

The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase
por: Shirazian, Pejman, et al.
Publicado: (2016)

Back to the future: the amazing journey of the therapeutic anti-leukemia enzyme asparaginase Erwinia chrysanthemi
por: Tong, Wing H., et al.
Publicado: (2023)

Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells
por: Komatsu, Keiko, et al.
Publicado: (1989)

7q35 Microdeletion and 15q13.3 and Xp22.33 Microduplications in a Patient with Severe Myoclonic Epilepsy, Microcephaly, Dysmorphisms, Severe Psychomotor Delay and Intellectual Disability
por: Paduano, Francesco, et al.
Publicado: (2020)

Case Report: Identification of a Novel Pathogenic Germline TP53 Variant in a Family With Li–Fraumeni Syndrome
por: Paduano, Francesco, et al.
Publicado: (2021)

Optimization of Culture Conditions for Production of the Anti-Leukemic Glutaminase Free L-Asparaginase by Newly Isolated Streptomyces olivaceus NEAE-119 Using Response Surface Methodology
por: El-Naggar, Noura El-Ahmady, et al.
Publicado: (2015)

In Silico Design of a Chimeric Humanized L-asparaginase
por: Pedroso, Alejandro, et al.
Publicado: (2023)

The Variant p.Ala84Pro Is Causative of X-Linked Hypophosphatemic Rickets: Possible Relationship with Burosumab Swinging Response in Adults
por: Zagari, Maria Carmela, et al.
Publicado: (2022)

The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells
por: D’Agostino, Sabrina, et al.
Publicado: (2018)

RNAi-mediated downregulation of asparaginase-like protein 1 inhibits growth and promotes apoptosis of human cervical cancer line SiHa
por: Lv, Xiao-Feng, et al.
Publicado: (2018)

STUDIES ON THE MECHANISM OF TUMOR INHIBITION BY L-ASPARAGINASE : EFFECTS OF THE ENZYME ON ASPARAGINE LEVELS IN THE BLOOD, NORMAL TISSUES, AND 6C3HED LYMPHOMAS OF MICE: DIFFERENCES IN ASPARAGINE FORMATION AND UTILIZATION IN ASPARAGINASE-SENSITIVE AND -RESISTANT LYMPHOMA CELLS
por: Broome, J. D.
Publicado: (1968)

Studies on Optimization of Growth Parameters for L-Asparaginase Production by Streptomyces ginsengisoli
por: Deshpande, Neelima, et al.
Publicado: (2014)

Optimization of Growth Conditions for Purification and Production of L-Asparaginase by Spirulina maxima
por: Abd El Baky, Hanaa H., et al.
Publicado: (2016)

Profiling Enzyme Activity of l-Asparaginase II by NMR-Based Methyl Fingerprinting at Natural Abundance
por: Nag, Rachayita, et al.
Publicado: (2023)

Effects of vinegar–egg on growth inhibition, differentiation human leukemic U937 cells and its immunomodulatory activity
por: Wang, Shiu-Yu, et al.
Publicado: (2017)

Expression of a recombinant bacterial l-asparaginase in human cells
por: Dantas, Raquel Caminha, et al.
Publicado: (2019)

Allergic Reactions to E. coli Asparaginase are Associated with Decreased Asparaginase Activity in an Indonesian Pediatric Population with ALL
por: Sari, Nur Melani, et al.
Publicado: (2023)

Safety evaluation of the food enzyme asparaginase from the genetically modified Bacillus subtilis strain NZYM‐CK
por: Lambré, Claude, et al.
Publicado: (2023)

Safety evaluation of the food enzyme asparaginase from the genetically modified Aspergillus oryzae strain NZYM‐OA
por: Lambré, Claude, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_45pr6pe40crhej4q9tl2s0stet