Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics

Cholera is a life-threatening disease in many countries, and new drugs are clearly needed. C-glycosidic antagonists may serve such a purpose. Here we report atomic-resolution crystal structures of three such compounds in complexes with the cholera toxin. The structures give unprecedented atomic deta...

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Detalles Bibliográficos
Autores principales: Heggelund, Julie Elisabeth, Mackenzie, Alasdair, Martinsen, Tobias, Heim, Joel Benjamin, Cheshev, Pavel, Bernardi, Anna, Krengel, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443773/
https://www.ncbi.nlm.nih.gov/pubmed/28539625
http://dx.doi.org/10.1038/s41598-017-02179-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443773/
https://www.ncbi.nlm.nih.gov/pubmed/28539625
http://dx.doi.org/10.1038/s41598-017-02179-0

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