The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage

A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H7N9 isola...

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Detalles Bibliográficos
Autores principales: Li, Weixuan, Lee, Horace Hok Yeung, Li, Run Feng, Zhu, Huachen Maria, Yi, Guan, Peiris, Joseph Sriyal Malik, Yang, Zi Feng, Mok, Chris Ka Pun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443809/
https://www.ncbi.nlm.nih.gov/pubmed/28539661
http://dx.doi.org/10.1038/s41598-017-02598-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443809/
https://www.ncbi.nlm.nih.gov/pubmed/28539661
http://dx.doi.org/10.1038/s41598-017-02598-z

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