Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets

Glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. However, the precise molecular mechanisms underlying these processes are not clearly understood. Here, we demonstrated that glucokinase activation using a glucokinase activator (GKA)...

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Detalles Bibliográficos
Autores principales: Okuyama, Tomoko, Shirakawa, Jun, Yanagisawa, Hiromi, Kyohara, Mayu, Yamazaki, Shunsuke, Tajima, Kazuki, Togashi, Yu, Terauchi, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443834/
https://www.ncbi.nlm.nih.gov/pubmed/28539593
http://dx.doi.org/10.1038/s41598-017-02535-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443834/
https://www.ncbi.nlm.nih.gov/pubmed/28539593
http://dx.doi.org/10.1038/s41598-017-02535-0

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