Microbial trimethylamine-N-oxide as a disease marker: something fishy?

Production of trimethylamine-N-oxide (TMAO) via the gut microbiota has recently been proposed as an important pathophysiological mechanism linking ingestion of ‘unhealthy foods’, such as beef (containing carnitine) and eggs (containing choline), and the development of atherosclerosis. Hence, TMAO ha...

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Detalles Bibliográficos
Autores principales: Landfald, Bjarne, Valeur, Jørgen, Berstad, Arnold, Raa, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444358/
https://www.ncbi.nlm.nih.gov/pubmed/28588431
http://dx.doi.org/10.1080/16512235.2017.1327309
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author Landfald, Bjarne
Valeur, Jørgen
Berstad, Arnold
Raa, Jan
author_facet Landfald, Bjarne
Valeur, Jørgen
Berstad, Arnold
Raa, Jan
author_sort Landfald, Bjarne
collection PubMed
description Production of trimethylamine-N-oxide (TMAO) via the gut microbiota has recently been proposed as an important pathophysiological mechanism linking ingestion of ‘unhealthy foods’, such as beef (containing carnitine) and eggs (containing choline), and the development of atherosclerosis. Hence, TMAO has gained attention as a novel biomarker for cardiovascular disease. However, fish and seafood contain considerable amounts of TMAO and are generally accepted as cardioprotective: a puzzling paradox that seems to have been neglected. We suspect that the TMAO story may be a red herring.
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spelling pubmed-54443582017-06-06 Microbial trimethylamine-N-oxide as a disease marker: something fishy? Landfald, Bjarne Valeur, Jørgen Berstad, Arnold Raa, Jan Microb Ecol Health Dis Review Article Production of trimethylamine-N-oxide (TMAO) via the gut microbiota has recently been proposed as an important pathophysiological mechanism linking ingestion of ‘unhealthy foods’, such as beef (containing carnitine) and eggs (containing choline), and the development of atherosclerosis. Hence, TMAO has gained attention as a novel biomarker for cardiovascular disease. However, fish and seafood contain considerable amounts of TMAO and are generally accepted as cardioprotective: a puzzling paradox that seems to have been neglected. We suspect that the TMAO story may be a red herring. Taylor & Francis 2017-05-19 /pmc/articles/PMC5444358/ /pubmed/28588431 http://dx.doi.org/10.1080/16512235.2017.1327309 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Landfald, Bjarne
Valeur, Jørgen
Berstad, Arnold
Raa, Jan
Microbial trimethylamine-N-oxide as a disease marker: something fishy?
title Microbial trimethylamine-N-oxide as a disease marker: something fishy?
title_full Microbial trimethylamine-N-oxide as a disease marker: something fishy?
title_fullStr Microbial trimethylamine-N-oxide as a disease marker: something fishy?
title_full_unstemmed Microbial trimethylamine-N-oxide as a disease marker: something fishy?
title_short Microbial trimethylamine-N-oxide as a disease marker: something fishy?
title_sort microbial trimethylamine-n-oxide as a disease marker: something fishy?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444358/
https://www.ncbi.nlm.nih.gov/pubmed/28588431
http://dx.doi.org/10.1080/16512235.2017.1327309
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